Research chemicals for laboratory use only
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Semaglutide is a GLP-1 receptor agonist analogue with an extended half-life relative to native GLP-1, achieved through fatty acid modification that enables albumin binding and resistance to DPP-4 enzymatic degradation. It is one of the most widely characterized reference compounds in in-vitro incretin and receptor-signaling research.
Semaglutide binds to GLP-1 receptors expressed in pancreatic beta-cell, hypothalamic, and gastrointestinal tissue models. Receptor activation drives glucose-dependent insulinotropic signaling and downstream cAMP pathway activity. Its prolonged half-life makes it a useful reference compound for studying sustained GLP-1 receptor engagement in preclinical in-vitro models.
Semaglutide is commonly used as a reference compound in in-vitro GLP-1 receptor-binding assays, comparative incretin agonist studies, and receptor-signaling characterization alongside Tirzepatide and Retatrutide.
Lyophilized Semaglutide 10mg at high purity, independently third-party tested. Molecular weight: 4113.6 Da. Batch SEM010-001. COA included with every order.
Store at -20°C prior to reconstitution. Reconstitute with sterile bacteriostatic water. Once in solution, store at 4°C and use within 28 days.
For research use only. Not for human or veterinary use.
Structure, CAS and molecular data, mechanism, storage and published literature: see our Semaglutide research reference.
Original price was: $100.00.$50.00Current price is: $50.00.
| Molecular Weight | 4113.6 Da |
|---|---|
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Sequence | H-Aib-E-G-T-F-T-S-D-V-S-S-Y-L-E-G-Q-A-A-K*-E-F-I-A-W-L-V-R-G-R-G-OH (31 aa; K* = Lys26 acylated with C18 diacid via γGlu-2×OEG) |
| CAS Number | 910463-68-2 |
| Batch Number | SEM010-001 |
| Appearance | White to off-white lyophilized powder |
| Storage | -20°C / -4°F (lyophilized); 4°C / 39°F reconstituted in Bacteriostatic Water, use within 28 days |
| Solubility | Soluble in water at 1 mg/mL |
| Size | 5mg, 10mg |
|---|
Research Summary: The following information is provided for research context only.
Semaglutide is a GLP-1 receptor agonist analogue with an extended half-life relative to native GLP-1, achieved through fatty acid modification that enables albumin binding and resistance to DPP-4 enzymatic degradation. It is one of the most widely characterized reference compounds in in-vitro incretin and receptor-signaling research.
Semaglutide binds to GLP-1 receptors expressed in pancreatic beta-cell, hypothalamic, and gastrointestinal tissue models. Receptor activation drives glucose-dependent insulinotropic signaling and downstream cAMP pathway activity. Its prolonged half-life makes it a useful reference compound for studying sustained GLP-1 receptor engagement in preclinical in-vitro models.
Semaglutide is commonly used as a reference compound in in-vitro GLP-1 receptor-binding assays, comparative incretin agonist studies, and receptor-signaling characterization alongside Tirzepatide and Retatrutide.
Lyophilized Semaglutide 10mg at high purity, independently third-party tested. Molecular weight: 4113.6 Da. Batch SEM010-001. COA included with every order.
Store at -20°C prior to reconstitution. Reconstitute with sterile bacteriostatic water. Once in solution, store at 4°C and use within 28 days.
For research use only. Not for human or veterinary use.
Structure, CAS and molecular data, mechanism, storage and published literature: see our Semaglutide research reference.
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