CJC-1295 No DAC + Ipamorelin: Research Reference
Research Use Only. This page is a technical reference for in-vitro laboratory research. Reserve Research compounds are not for human or veterinary use, and nothing here is guidance for administration of any kind.
In simple words
This is a mix of two lab-made peptides. Peptides are short chains of amino acids. One is CJC-1295 No DAC. The other is ipamorelin.
Each one turns on a different switch on cells in a gland in the head. Both switches help control growth hormone. Scientists use the mix to see how the two switches work together.
Reserve Research sells this mix only for lab research. See CJC-1295 No DAC + Ipamorelin on our product page →
CJC-1295 No DAC + Ipamorelin is a research blend of two synthetic peptides that act on the two main receptors controlling growth hormone (GH) release from the pituitary. CJC-1295 No DAC (also called Modified GRF 1-29) is a 29-amino-acid analogue of growth hormone-releasing hormone that activates the GHRH receptor. Ipamorelin is a pentapeptide that activates the ghrelin receptor (GHSR-1a). CJC-1295 No DAC is C152H252N44O42 (≈3,367.9 g/mol); ipamorelin is C38H49N9O5 (≈711.9 g/mol, CAS 170851-70-4).
CJC-1295 No DAC + Ipamorelin key facts
| CJC-1295 No DAC | Ipamorelin | |
|---|---|---|
| Also called | Modified GRF (1-29), tetrasubstituted GRF(1-29) | Ipamorelin |
| Class | GHRH analogue (29 aa) | Growth hormone secretagogue (pentapeptide) |
| Sequence | Y-(D-Ala)-D-A-I-F-T-Q-S-Y-R-K-V-L-A-Q-L-S-A-R-K-L-L-Q-D-I-L-S-R-NH2 | Aib-His-D-2Nal-D-Phe-Lys-NH2 |
| Formula | C152H252N44O42 | C38H49N9O5 |
| Molecular weight | ≈3,367.9 g/mol | ≈711.9 g/mol |
| CAS | 863288-34-0 (as commonly listed) | 170851-70-4 |
| Receptor | GHRH receptor | GHSR-1a (ghrelin receptor) |
Structure
CJC-1295 No DAC is the first 29 residues of human GHRH (the shortest fully active fragment, also known as sermorelin) with four substitutions that make it more resistant to enzymatic breakdown: D-Ala at position 2, Gln at 8, Ala at 15 and Leu at 27. The C-terminus is amidated.
“No DAC” means it lacks the Drug Affinity Complex, a maleimidopropionyl-lysine extension that lets the related compound CJC-1295 with DAC bind covalently to albumin. The two are different molecules: CJC-1295 with DAC is ≈3,647 g/mol and carries its own CAS number (446262-90-4).
Ipamorelin is a five-residue peptide with three non-standard building blocks: α-aminoisobutyric acid (Aib), D-2-naphthylalanine (D-2Nal) and D-phenylalanine, plus a C-terminal amide. It was developed at Novo Nordisk as a ghrelin-receptor agonist.
Mechanisms studied in research models
- Two separate receptors. GHRH-receptor agonists and ghrelin-receptor agonists act through different pathways in pituitary somatotrophs (Gs/cAMP for the GHRH receptor; Gq/calcium for GHSR-1a). Pairing them lets researchers study how the two inputs combine.
- Ipamorelin selectivity. In the discovery study, ipamorelin released GH from rat pituitary cells in vitro. In swine, it raised GH without raising ACTH or cortisol above control at exposures far above those needed for GH release, unlike the older secretagogues GHRP-6 and GHRP-2 (Raun et al., 1998).
- Limited primary literature for Mod GRF 1-29. Most published CJC-1295 studies use the DAC version. The tetrasubstituted analogue without DAC has little dedicated primary literature, so its properties are mostly inferred from GHRH(1-29) structure–activity work.
Laboratory handling and storage
- Lyophilized powder: store at −20 °C, sealed and dry, away from light. Let the vial reach room temperature before opening.
- Solvent: both peptides are water-soluble. Labs commonly use sterile bacteriostatic water for multi-use stock solutions.
- Prepared solutions: keep at 2–8 °C and avoid repeated freeze–thaw cycles. GHRH analogues are prone to degradation in solution, so prepare fresh stocks.
What a CJC-1295 No DAC + Ipamorelin certificate of analysis should show
- Identity: two distinct masses, one near 3,367.9 g/mol (CJC-1295 No DAC) and one near 711.9 g/mol (ipamorelin). A mass near 3,647 g/mol would indicate the DAC version instead.
- Content: the amount of each peptide in the vial.
- Batch traceability: a lot number that matches the vial label.
Every Reserve Research batch is tested by an independent lab. You can look up any batch number on our COA verification page.
Frequently asked questions
What is CJC-1295 No DAC?
CJC-1295 No DAC (Modified GRF 1-29) is a 29-amino-acid GHRH analogue with four substitutions (D-Ala2, Gln8, Ala15, Leu27) and an amidated C-terminus. It activates the GHRH receptor.
What is the difference between CJC-1295 with DAC and without DAC?
CJC-1295 with DAC carries a reactive lysine extension that binds albumin and has a molecular weight near 3,647 g/mol. CJC-1295 No DAC lacks that extension and is about 3,367.9 g/mol. They are different molecules.
What is ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) that activates the ghrelin receptor, GHSR-1a. It was described as the first selective growth hormone secretagogue.
What is the CAS number for ipamorelin?
170851-70-4.
What are the molecular weights of CJC-1295 No DAC and ipamorelin?
About 3,367.9 g/mol (C152H252N44O42) and about 711.9 g/mol (C38H49N9O5).
Why are CJC-1295 No DAC and ipamorelin combined?
They act on two different receptors that both regulate GH release, so researchers use the pair to study how GHRH-receptor and ghrelin-receptor signaling interact.
How should the blend be stored?
Store the lyophilized powder at −20 °C, dry and protected from light. Keep reconstituted solutions at 2–8 °C and avoid repeated freeze–thaw cycles.
Is Reserve Research CJC-1295 No DAC + Ipamorelin sold for laboratory research only?
Yes. It is sold strictly for in-vitro laboratory research. It is not a drug or supplement, and it is not for human or veterinary use.
Research-grade CJC-1295 No DAC + Ipamorelin from Reserve Research
CJC-1295 No DAC + Ipamorelin is supplied as a lyophilized powder in sealed vials, independently tested batch by batch, with the COA available through the product page and /verify. Related: bacteriostatic water.
View CJC-1295 No DAC + Ipamorelin specifications and batch COA →
References
- Raun K, Hansen BS, Johansen NL, et al. European Journal of Endocrinology. 1998;139:552–561. doi:10.1530/eje.0.1390552
- Wikipedia, CJC-1295: sequence and structure of CJC-1295 with and without DAC.
Last reviewed: October 2026. This page summarizes published laboratory literature for reference. It makes no claims about the safety or effectiveness of any compound in humans or animals.