Research chemicals for laboratory use only
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Semaglutide is a GLP-1 receptor agonist analogue with an extended half-life relative to native GLP-1, achieved through fatty acid modification that enables albumin binding and resistance to DPP-4 enzymatic degradation. It has been one of the most widely studied compounds in metabolic and cardiovascular research over the past decade.
Semaglutide binds to GLP-1 receptors expressed in pancreatic beta cells, the hypothalamus, and the gastrointestinal tract. Activation of these receptors stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite via central hypothalamic pathways. Its prolonged half-life makes it a useful reference compound for studying sustained GLP-1 receptor engagement in preclinical models.
Semaglutide has been investigated in preclinical models of: type 2 diabetes and insulin resistance; obesity and energy balance; non-alcoholic steatohepatitis (NASH); cardiovascular risk and inflammation; and neurodegenerative conditions involving GLP-1 receptor pathways. It is commonly used as a reference compound in comparative incretin research alongside Tirzepatide and Retatrutide.
Lyophilized Semaglutide 10mg at 99%+ HPLC-UV purity. LCMS-confirmed identity. Molecular weight: 4113.6 Da. Batch SEM010-001. COA included with every order.
Store at -20°C prior to reconstitution. Reconstitute with sterile bacteriostatic water. Once in solution, store at 4°C and use within 28 days.
For research use only. Not for human or veterinary use.
$55.00
| Purity | ≥99% (HPLC-UV) |
|---|---|
| Purity Method | HPLC-UV |
| Molecular Weight | 4113.6 Da |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| CAS Number | 910463-68-6 |
| Batch Number | SEM010-001 |
| Appearance | White to off-white lyophilized powder |
| Endotoxin | Tested (LAL); see batch COA for value |
| Storage | -20°C / -4°F (lyophilized); 4°C / 39°F reconstituted in Bacteriostatic Water, use within 28 days |
| Solubility | Soluble in water at 1 mg/mL |
| Size | 5mg, 10mg |
|---|
Research Summary: The following information is provided for research context only.
Semaglutide is a GLP-1 receptor agonist analogue with an extended half-life relative to native GLP-1, achieved through fatty acid modification that enables albumin binding and resistance to DPP-4 enzymatic degradation. It has been one of the most widely studied compounds in metabolic and cardiovascular research over the past decade.
Semaglutide binds to GLP-1 receptors expressed in pancreatic beta cells, the hypothalamus, and the gastrointestinal tract. Activation of these receptors stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite via central hypothalamic pathways. Its prolonged half-life makes it a useful reference compound for studying sustained GLP-1 receptor engagement in preclinical models.
Semaglutide has been investigated in preclinical models of: type 2 diabetes and insulin resistance; obesity and energy balance; non-alcoholic steatohepatitis (NASH); cardiovascular risk and inflammation; and neurodegenerative conditions involving GLP-1 receptor pathways. It is commonly used as a reference compound in comparative incretin research alongside Tirzepatide and Retatrutide.
Lyophilized Semaglutide 10mg at 99%+ HPLC-UV purity. LCMS-confirmed identity. Molecular weight: 4113.6 Da. Batch SEM010-001. COA included with every order.
Store at -20°C prior to reconstitution. Reconstitute with sterile bacteriostatic water. Once in solution, store at 4°C and use within 28 days.
For research use only. Not for human or veterinary use.
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