Semaglutide

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Research-grade Semaglutide — GLP-1 receptor agonist analogue, lyophilized, high purity. Independently third-party tested. Each RR vial has a QR code linking to its batch’s independent COA. For research use only.

Research background, specifications & storage
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Batch documentation: see COA & Testing tab
For Research Use Only. Not for human or veterinary use.

Additional information

Molecular Weight4113.6 Da
Molecular FormulaC₁₈₇H₂₉₁N₄₅O₅₉
SequenceH-Aib-E-G-T-F-T-S-D-V-S-S-Y-L-E-G-Q-A-A-K*-E-F-I-A-W-L-V-R-G-R-G-OH (31 aa; K* = Lys26 acylated with C18 diacid via γGlu-2×OEG)
CAS Number910463-68-2
Batch NumberSEM010-001
AppearanceWhite to off-white lyophilized powder
Storage-20°C / -4°F (lyophilized); 4°C / 39°F reconstituted in Bacteriostatic Water, use within 28 days
SolubilitySoluble in water at 1 mg/mL
Size

10mg

COA & Testing

Independent third-party lab reports for the batches shown below. Only results the laboratory reported for that batch are shown. Look up any vial code or browse all products at batch reports.

10 mg

SEM010-001Current batch — shipping now
Purity
99.594%
Measured peptide content
12.71 mg per vial
Endotoxin test
Pass

Research Summary: The following information is provided for research context only.

Semaglutide Research Overview

Semaglutide is a GLP-1 receptor agonist analogue with an extended half-life relative to native GLP-1, achieved through fatty acid modification that enables albumin binding and resistance to DPP-4 enzymatic degradation. It is one of the most widely characterized reference compounds in in-vitro incretin and receptor-signaling research.

Mechanism of Action

Semaglutide binds to GLP-1 receptors expressed in pancreatic beta-cell, hypothalamic, and gastrointestinal tissue models. Receptor activation drives glucose-dependent insulinotropic signaling and downstream cAMP pathway activity. Its prolonged half-life makes it a useful reference compound for studying sustained GLP-1 receptor engagement in preclinical in-vitro models.

Research Applications

Semaglutide is commonly used as a reference compound in in-vitro GLP-1 receptor-binding assays, comparative incretin agonist studies, and receptor-signaling characterization alongside Tirzepatide and Retatrutide.

Compound Specifications

Lyophilized Semaglutide 10mg at high purity, independently third-party tested. Molecular weight: 4113.6 Da. Batch SEM010-001. Each RR vial has a QR code linking to its batch’s independent COA (also in the COA & Testing tab and at /verify). No paper COA ships with orders.

Storage and Handling

Store at -20°C prior to reconstitution. Reconstitute with sterile bacteriostatic water. Once in solution, store at 4°C and use within 28 days.

For research use only. Not for human or veterinary use.

Structure, CAS and molecular data, mechanism, storage and published literature: see our Semaglutide research reference.

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