BPC-157: Research Reference
Research Use Only. This page is a technical reference for in-vitro laboratory research. Reserve Research compounds are not for human or veterinary use, and nothing here is guidance for administration of any kind.
In simple words
BPC-157 is a chain of 15 amino acids. It is made in a lab. Amino acids are the building blocks of proteins. Its pattern was copied from a protein found in stomach juice.
Scientists use it in lab dishes and lab animals. They study how cells move and how cells send signals to grow new blood vessels.
Reserve Research sells BPC-157 only for lab research. See BPC-157 on our product page →
BPC-157 (Body Protection Compound-157, pentadecapeptide BPC 157) is a synthetic 15-amino-acid peptide, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Its sequence is a partial sequence of a protein found in human gastric juice. It was described by Sikiric and colleagues in Zagreb in the early 1990s. Laboratories study it in cell-culture and animal models of angiogenesis signaling, fibroblast migration and growth-factor receptor expression. Its CAS number is 137525-51-0, its formula is C62H98N16O22, and its molecular weight is about 1,419.5 g/mol.
BPC-157 key facts
| Name | BPC-157 |
|---|---|
| Synonyms | Body Protection Compound-157, pentadecapeptide BPC 157, PL 14736 |
| Compound class | Synthetic linear peptide (15 amino acids) |
| Sequence | G-E-P-P-P-G-K-P-A-D-D-A-G-L-V (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val), free termini |
| CAS number | 137525-51-0 |
| Molecular formula | C62H98N16O22 |
| Molecular weight | ≈1,419.5 g/mol (free peptide) |
| Salt forms | Commonly supplied as the acetate; an arginate salt also exists. Salt changes the mass per vial, not the peptide |
| Appearance | White lyophilized powder |
| Solubility | Freely soluble in water |
| Storage (lyophilized) | −20 °C, dry, protected from light |
Structure
BPC-157 is a short, unmodified linear peptide with no cysteines, no lipid chain and no non-coded amino acids. Its proline-rich N-terminal region (Pro-Pro-Pro) gives it unusual stability for a peptide of its size, and it is reported to be stable in gastric juice. The name refers to the parent “body protection compound” protein from which the 15-residue sequence was taken.
Mechanisms studied in research models
- VEGFR2 signaling in endothelial cells. In human umbilical vein endothelial cells (HUVECs), BPC-157 increased VEGFR2 expression and phosphorylation and activated an Akt–eNOS pathway. It also increased tube formation in vitro and vessel formation in chick chorioallantoic membrane and rat hindlimb models (Hsieh et al., 2017).
- Fibroblast migration. In cultured rat tendon fibroblasts, BPC-157 increased outgrowth from tendon explants, cell survival under stress and cell migration, with increased phosphorylation of FAK and paxillin (Chang et al., 2011).
- Growth hormone receptor expression. In the same cell type, BPC-157 increased growth hormone receptor mRNA and protein in a concentration- and time-dependent way, with JAK2 pathway involvement (Chang et al., 2014).
- Gene expression in tissue models. In a rat granulation-tissue model, BPC-157 (as PL 14736) changed expression of the early-response gene egr-1 and its repressor nab2 (Tkalčević et al., 2007).
Most published BPC-157 work comes from a small number of research groups, and much of it from one group. Independent replication is limited, so treat findings as preliminary.
Laboratory handling and storage
- Lyophilized powder: store at −20 °C, sealed and dry, away from light. Let the vial reach room temperature before opening.
- Solvent: BPC-157 dissolves readily in water. Labs commonly use sterile bacteriostatic water for multi-use stock solutions.
- Prepared solutions: keep at 2–8 °C and avoid repeated freeze–thaw cycles.
What a BPC-157 certificate of analysis should show
- Identity: mass consistent with ≈1,419.5 g/mol for the free peptide.
- Purity: chromatographic purity reported for the specific batch.
- Batch traceability: a lot number that matches the vial label.
Every Reserve Research batch is tested by an independent lab. You can look up any batch number on our COA verification page.
Frequently asked questions
What is BPC-157?
BPC-157 is a synthetic 15-amino-acid peptide (GEPPPGKPADDAGLV) whose sequence comes from a protein found in human gastric juice. Laboratories use it to study angiogenesis signaling, fibroblast migration and growth-factor receptor expression.
What is the CAS number for BPC-157?
137525-51-0.
What is the molecular weight and formula of BPC-157?
C62H98N16O22, with a molecular weight of about 1,419.5 g/mol for the free peptide.
What is the amino-acid sequence of BPC-157?
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV).
What does BPC stand for?
Body Protection Compound. The number 157 identifies the 15-residue fragment taken from the larger parent protein.
What is the difference between BPC-157 acetate and BPC-157 arginate?
They are different salt forms of the same peptide. The salt affects the total mass in the vial and handling properties, not the peptide sequence.
How should BPC-157 be stored?
Store the lyophilized powder at −20 °C, dry and protected from light. Keep reconstituted solutions at 2–8 °C and avoid repeated freeze–thaw cycles.
Is Reserve Research BPC-157 sold for laboratory research only?
Yes. It is sold strictly for in-vitro laboratory research. It is not a drug or supplement, and it is not for human or veterinary use.
Research-grade BPC-157 from Reserve Research
BPC-157 is supplied as a lyophilized powder in sealed vials, independently tested batch by batch, with the COA available through the product page and /verify. Related: TB-500 reference, GHK-Cu reference and bacteriostatic water.
References
- Sikiric P, Petek M, Rucman R, et al. Journal of Physiology (Paris). 1993;87(5):313–327. doi:10.1016/0928-4257(93)90038-U
- Hsieh MJ, Liu HT, Wang CN, et al. Journal of Molecular Medicine. 2017;95(3):323–333. doi:10.1007/s00109-016-1488-y
- Chang CH, Tsai WC, Lin MS, et al. Journal of Applied Physiology. 2011;110(3):774–780. doi:10.1152/japplphysiol.00945.2010
- Chang CH, Tsai WC, Hsu YH, Pang JH. Molecules. 2014;19(11):19066–19077. doi:10.3390/molecules191119066
- Tkalčević VI, Čužić S, Brajša K, et al. European Journal of Pharmacology. 2007;570(1–3):212–221. doi:10.1016/j.ejphar.2007.05.072
Last reviewed: October 2026. This page summarizes published laboratory literature for reference. It makes no claims about the safety or effectiveness of any compound in humans or animals.